Last week brought welcome news about the apparent effectiveness of a potential Covid-19 vaccine. While the challenges of manufacturing and distributing the vaccine lie ahead, this column argues that the most difficult challenge may actually be getting people to take it. A September survey of more than 10,000 Americans showed that only a slim majority of adult respondents would definitely or probably get a vaccine to prevent Covid-19, were it available today. A 2018 study shows that vaccine scepticism is even greater in a number of other countries. Hope lies in the possibility of a more consistent and effective public policy response, in which governments’ non-pharmaceutical interventions produce positive results, in turn fostering confidence in the safety and efficacy of any vaccine they endorse and distribute.